Thermo Fisher Scientific RBM25/RED120 Polyclonal Antibody
RBM25/RED120 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 실험에 사용 가능. RNA 스플라이싱 및 세포사멸 관련 연구에 적합. 액상 형태로 제공되며 4°C에서 보관. 연구용으로만 사용.
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- A301068Ax (2개 옵션)
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RBM25/RED120 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and 525 of Human RNA binding motif protein 25 (Arg/Glu/Asp-rich protein, 120 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.
Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression.
Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression.
When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5′-splice site (5′-ss) selection, whereas its depletion causes accumulation of antiapoptotic isoform L.
Promotes BCL2L1 isoform S 5′-ss usage through the 5′-CGGGCA-3′ RNA sequence.
Its association with LUC7L3 promotes U1 snRNP binding to a weak 5′ ss in a 5′-CGGGCA-3′-dependent manner.
Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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