Thermo Fisher Scientific RBM25/RED120 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. Overexpression stimulates proapoptotic BCL2L1 isoform S 5′-splice site selection, while depletion causes accumulation of antiapoptotic isoform L. Promotes BCL2L1 isoform S 5′-ss usage through the 5′-CGGGCA-3′ RNA sequence. Association with LUC7L3 promotes U1 snRNP binding to a weak 5′ ss in a 5′-CGGGCA-3′-dependent manner. Binds to the exonic splicing enhancer 5′-CGGGCA-3′ RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in generation of an abnormal and truncated splice form of SCN5A in heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.