Thermo Fisher Scientific TRPM4 Polyclonal Antibody
TRPM4 단백질을 인식하는 Goat Polyclonal Antibody로, Mouse 및 Rat 시료에 반응. Western Blot과 IHC에 사용 가능하며, 합성 펩타이드 항원을 이용해 제작됨. 연구용으로만 사용하며 안정적 장기 보관 가능.
- 카탈로그번호
- OST00345W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of rat TRPM4 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPM4.
Target Information
TRPM4 is a calcium-activated, non-selective cation channel that mediates membrane depolarization. Although activated by increased intracellular Ca²⁺, it is impermeable to Ca²⁺ itself. It transports monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), contributing to depolarization of the membrane.
It plays a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells, and more. TRPM4 participates in T-cell activation by modulating Ca²⁺ oscillations required for NFAT-dependent IL2 production, and is involved in myogenic constriction of cerebral arteries.
Additionally, it controls insulin secretion in pancreatic beta-cells and may affect pacemaking or irregular electrical activity under Ca²⁺ overload. TRPM4 influences T-helper cell motility and cytokine production via calcium signaling and NFATC1 localization, and enhances cell proliferation through β-catenin signaling upregulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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