Thermo Fisher Scientific Fas Recombinant Rabbit Monoclonal Antibody (JJ0942)
Human Fas 단백질(aa 130-335)을 인식하는 JJ0942 클론의 Recombinant Rabbit Monoclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 높은 특이성과 민감도, 로트 간 일관성 제공. 단백질 A 정제, 액상 형태, 1 mg/mL 농도.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ0942 |
| Immunogen | Recombinant protein within Human Fas aa 130–335 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809766 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble 26 kDa form. Activation of FAS leads to aggregation of FADD, formation of the death-inducing signaling complex (DISC), and caspase activation, triggering apoptosis.
FAS can activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK pathways, playing roles in proliferation and apoptosis regulation. Multiple alternatively spliced isoforms exist, some lacking transmembrane domains that may negatively regulate apoptosis. The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer and is involved in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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