Thermo Fisher Scientific IDH1 (Isocitrate Dehydrogenase) Monoclonal Antibody (IDH1/1152)
인간 IDH1 단백질을 인식하는 mouse monoclonal antibody로 다양한 응용(WB, IHC, ICC, Flow)에 사용 가능. 단백질 A/G 정제, PBS buffer에 보존, 무보존제. 연구용으로만 사용.
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- 3417-MSM2-P1ABX
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Thermo Fisher Scientific IDH1 (Isocitrate Dehydrogenase) Monoclonal Antibody (IDH1/1152)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IDH1/1152 |
| Immunogen | Recombinant fragment of human IDH1 protein (around aa 281–414) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors. Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases localized to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one mitochondrial and one predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer.
The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence, suggesting roles in NADPH regeneration for intraperoxisomal reductions and peroxisomal reactions consuming 2-oxoglutarate. The cytoplasmic enzyme plays a key role in cytoplasmic NADPH production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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