Thermo Fisher Scientific IDH1-R132H (Isocitrate Dehydrogenase) Recombinant Rabbit Monoclonal Antibody (IDH1/7277R)
IDH1-R132H 변이 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체입니다. IHC(P) 및 IHC(PFA) 실험에 사용 가능하며, HEK293 세포에서 발현된 고순도 단백질 A/G 정제 항체입니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IDH1/7277R |
| Immunogen | Recombinant fragment of human IDH1 (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent enzymes localized to the mitochondrial matrix and two NADP(+)-dependent enzymes, one mitochondrial and one cytosolic.
The cytosolic NADP(+)-dependent isozyme encoded by this gene functions in cytoplasmic NADPH production and peroxisomal metabolism. This antibody is specific for the IDH1 mutant R132H.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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