Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53), PE
CD33 단백질을 인식하는 WM53 클론의 Mouse IgG1 단일클론 항체로 PE 형광체가 결합된 제품입니다. 유세포 분석(Flow Cytometry)에 적합하며 인간 및 비인간 영장류에 반응합니다. AML 세포를 면역원으로 사용하였으며, 4°C 암소 보관 권장됩니다.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WM53 |
| Immunogen | Human AML cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534573 |
Additional Formats
- Unconjugated (MA5-44017)
- APC (A15727)
- FITC (A15763)
- PerCP (A15804)
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells, and mast cells. It is absent on platelets, lymphocytes, erythrocytes, and hematopoietic stem cells.
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, contributing to receptor signaling and regulation. CD33 is expressed on myelomonocytic lineage cells, binds sialic acid residues on cell surface glycans, and serves as a therapeutic target for acute myeloid leukemia (AML). It is present on granulocyte and macrophage precursors in bone marrow but absent on pluripotent stem cells. CD33 is also a marker for peripheral monocytes and useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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