Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (Bcl2/100), PE

Applications

• Flow Cytometry (Flow): 20 µL/1x10⁶ cells
• View 2 publications

Product Specifications

Additional Formats

• FITC
• Request custom conjugation

Product Specific Information

This antibody recognizes Bcl-2, a 26 kDa intracellular proto-oncogene with anti-apoptotic effects. It is expressed in the outer mitochondrial membrane, endoplasmic reticulum, and nuclear envelope.

Target Information

BCL-2 is a key regulator of apoptosis that can either inhibit or promote cell death. Members of the BCL-2 family interact through dimerization to modulate apoptosis.

• Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect.
• Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis.
  Overexpression or translocation of BCL-2 is associated with several human cancers, including B-cell lymphoma and prostate cancer. In follicular lymphoma, neoplastic germinal centers express high levels of BCL-2 protein, unlike normal germinal centers. Two transcript variants of BCL-2 differ at their C-terminal ends due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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