Thermo Fisher Scientific CD205 Monoclonal Antibody (HD30), PE
PE 형광으로 표지된 인간 CD205 단일클론 항체로, 수지상세포 및 흉선 상피세포 분석에 적합. Flow Cytometry에 최적화된 10 µL/10^6 cells 사용. 4°C 암소 보관, 동결 금지. 연구용 전용 제품.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 10 µL / 1×10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HD30 |
| Immunogen | Recombinant Fc-tagged human CD205 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534575 |
Product Specific Information
This antibody recognizes an extracellular epitope of CD205, an approximately 200 kDa C-type lectin transmembrane protein of the macrophage mannose receptor (MMR) family. CD205 is expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells, and monocytes.
Target Information
CD205 (LY75, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking, and presentation, enhancing antigen-specific T cell immunity. It is highly expressed by CD8⁺ dendritic cells and variably expressed by bone marrow Gr1⁺ cells, Langerhans cells, bone marrow–derived dendritic cells (BMDCs), and thymic epithelial cells. CD205 functions as an endocytic receptor that directs captured antigens to specialized processing regions and can modulate B lymphocyte proliferation.
Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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