Thermo Fisher Scientific CD163 Monoclonal Antibody (GHI/61), PE

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• APC conjugate: A15723
• Custom conjugation available: Request form

Product Specific Information

This antibody binds hemoglobin-haptoglobin complex.

Target Information

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It acts as a receptor for the hemoglobin-haptoglobin complex and protects tissues from oxidative damage caused by free hemoglobin. CD163 participates in iron recycling through endocytosis and heme degradation.
It is expressed exclusively on human monocytes and macrophages, particularly in the late phase of inflammation. CD163 is present on all circulating monocytes and most tissue macrophages except certain lymphoid and dendritic cells. Expression is enhanced by IL-10, IL-6, and dexamethasone, while LPS and PMA induce shedding of CD163 into plasma or supernatant.
Binding of hemoglobin/haptoglobin complexes is calcium- and pH-dependent, showing higher affinity for HP1F phenotype complexes. CD163 also triggers intracellular signaling involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL-6 and CSF1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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