Thermo Fisher Scientific DUSP8 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DUSP8 residues 250–300. Validated for Western blot (1:100–1:2,000). Unconjugated liquid form, 0.5 mg/mL concentration. Ideal for studying MAPK pathway regulation and DUSP8 expression in brain, heart, and mus...
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Thermo Fisher Scientific DUSP8 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:100–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 250–300 of human DUSP8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1074120 |
Product Specific Information
Suggested positive control: HeLa whole cell extract.
Target Information
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the dual specificity phosphatase family show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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