Thermo Fisher Scientific DUSP8 Polyclonal Antibody

Thermo Fisher Scientific DUSP8 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:100–1:2,000

Product Specifications

Product Specific Information

Suggested positive control: HeLa whole cell extract.

Target Information

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the dual specificity phosphatase family show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.