Thermo Fisher Scientific CRM1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-41634 detects Exportin-1 in chimpanzee, bovine, canine, and human samples.
This antibody is predicted to cross-react with mouse and rat samples based on sequence homology.
Suggested positive control: Jurkat whole cell lysate.

Target Information

Exportin-1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembly of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of nuclear export is conferred by the asymmetric distribution of GTP- and GDP-bound forms of Ran between cytoplasm and nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.