Thermo Fisher Scientific IFN gamma Chimeric Recombinant Rabbit Monoclonal Antibody (D9D10)
인간 IFN-γ에 특이적으로 결합하는 키메릭 재조합 토끼 단클론 항체입니다. Western blot, Flow cytometry, ELISA 등 다양한 어세이에 사용 가능합니다. HEK293 세포에서 발현되었으며 Protein A로 정제되었습니다. 연구용으로만 사용하십시오.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | D9D10 |
| Immunogen | FPLC-purified natural human IFN-γ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074276 |
Product Specific Information
Specificity: Binds human interferon gamma, a dimerized soluble cytokine that is the only member of the type II class of interferons.
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, and cytokines.
It is a dimeric glycoprotein composed of two 146 amino acid subunits, forming a functional homodimer (~45 kDa).
On SDS-PAGE, IFN gamma appears as 25, 20, and 15.5 kDa bands due to differential glycosylation.
주요 기능
- 항바이러스 및 항종양 증식 억제 활성
- MHC class I 및 II 발현 유도
- 대식세포 활성화
- B 림프구의 면역글로불린 분비 촉진
- 다른 사이토카인과의 상승작용
Human IFN gamma does not cross-react with mouse IFN gamma.
It is upregulated by IL-2, FGF basic, EGF, and downregulated by vitamin D3 or DMN.
Mutations in the IFN gamma gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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