Thermo Fisher Scientific NOTCH2 Chimeric Recombinant Rabbit Monoclonal Antibody (B9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2 but not NRR1.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved protein in the Notch signaling pathway. It is a type I transmembrane protein with an extracellular domain containing multiple EGF-like repeats and an intracellular domain with multiple distinct domains. NOTCH2 acts as a receptor for membrane-bound ligands such as Jagged1, Jagged2, and Delta1, regulating cell-fate determination.
Mutations in NOTCH2 are associated with Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and various cardiac, skeletal, and ophthalmologic abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.