Thermo Fisher Scientific Laminin gamma-2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Laminins are extracellular matrix glycoproteins forming a major component of basement membranes. They play roles in cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Laminins consist of three non-identical chains (alpha, beta, and gamma) forming a cruciform structure. Each chain is a multidomain protein encoded by distinct genes, and various isoforms exist.

The Laminin gamma-2 chain (encoded by LAMC2) is highly homologous to gamma-1 but lacks domain VI and has shorter domains V, IV, and III. It is expressed in epithelial tissues such as skin, lung, and kidney, forming part of laminin-5 (alpha3beta3gamma2), which anchors epithelial cells to the basement membrane. Mutations in LAMC2 are associated with junctional epidermolysis bullosa, a blistering skin disorder. Two transcript variants have been described, differing in their 3' terminal exon splicing and expression patterns during development.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.