Thermo Fisher Scientific Aurora B (Proliferation Marker) Monoclonal Antibody (AURKB/1845)
Aurora B 단백질을 표지하는 Mouse monoclonal antibody로, 세포 증식 및 염색체 분리 연구에 적합. 인간 반응성, Protein A/G 정제, 액상 형태, 1 mg/mL 농도. IHC(P) 및 IHC(PFA) 응용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AURKB/1845 |
| Immunogen | Recombinant fragment (around aa 89–251) of human Aurora B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aurora kinases are associated with microtubules during chromosome movement and segregation.
AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to K-fibers.
This complex functions in chromosome alignment, separation, histone modification, and cytokinesis.
The chromosomal passenger complex (CPC) includes INCENP, survivin, and borealin, which regulate Aurora B’s activity, localization, and substrate specificity.
Two CPC forms exist during mitosis: one with all four members and another with INCENP and AurB.
AurB is overexpressed in several tumors, including breast and colon cancers, and may interact with Aurora-A kinase through a feedback mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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