Thermo Fisher Scientific Phospho-STAT5 alpha/beta (Ser726, Ser731) Polyclonal Antibody
STAT5 α/β 인산화(Ser726, Ser731) 부위를 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P)에서 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도. PBS/glycerol buffer, 4°C 또는 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Stat5a around the phosphorylation site of Serine 726 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553715 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 90 kDa.
- Purity >95% by SDS-PAGE.
Target Information
The protein encoded by this gene belongs to the STAT family of transcription factors. In response to cytokines and growth factors, STAT proteins are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators. This protein mediates responses to ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation through TEL/JAK2 fusion in myeloma and lymphoma is independent of external stimuli and essential for tumorigenesis. The mouse counterpart induces BCL2L1/BCL-X(L) expression, suggesting an anti-apoptotic role.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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