Thermo Fisher Scientific Phospho-INSR (Tyr1361) Polyclonal Antibody
인간, 마우스, 랫트 INSR 인산화 부위(Tyr1361)를 인식하는 폴리클로날 항체. Western blot 및 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 제품. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1361 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553711 |
Product Specific Information
- Detects endogenous protein at molecular weights of 95 and 156 kDa.
- Purity >95% by SDS-PAGE.
Target Information
INSR is a receptor tyrosine kinase that mediates insulin signaling. Binding of insulin to the extracellular domain stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR.
In humans, the INSR gene is located on chromosome 19.
Defects in INSR cause various insulin resistance syndromes, and IGF-1R defects may also lead to growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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