Thermo Fisher Scientific FANCD2 Monoclonal Antibody (103)
Human FANCD2 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot, ICC/IF, ELISA 등에 사용 가능. 고순도 Protein G 정제, 보존제 무첨가 PBS 용액 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific FANCD2 Monoclonal Antibody (Clone 103)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 103 |
| Immunogen | Human FANCD2 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_558878 |
Product Specific Information
Recommended positive controls: 293T, HeLa.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene result in Fanconi anemia complementation group D2, which affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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