Thermo Fisher Scientific PPFIBP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PPFIBP1. Recombinant protein control fragment (Product #RP-102023). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PPFIBP1,uniProtId:Q86W92-1,ncbiNodeId:9606,antigenRange:367-490,antigenLength:1011,antigenImageFileName:PA5-51663_PPFIBP1_Q86W92-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51663_PPFIBP1_Q86W92-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645815

Product Specific Information

Immunogen sequence: DAQGFSDLEK SPSPTPVMGS PSCDPFNTSV PEEFHTTILQ VSIPSLLPAT VSMETSEKSK LTPKPETSFE ENDGNIILGA TVDTQLCDKL LTSSLQKSSS LGNLKKETSD GEKETIQKTS EDRA

Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 67%.

Target Information

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.