Thermo Fisher Scientific USP51 Polyclonal Antibody
Thermo Fisher Scientific의 USP51 폴리클로날 항체로, 인간 USP51 단백질을 인식합니다. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼(40% 글리세롤) 내 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관이 권장됩니다.
- 카탈로그번호
- PA551667
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human USP51. Recombinant protein control fragment (Product # RP-92108) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649364 |
Product Specific Information
Immunogen sequence:
LRLIYQRFVW SGTPETRKRK AKSCICHVCS THMNRLHSCL SCVFFGCFTE KHIHKHAETK QHHLAVDLYH GVIYCFMCKD YVYDKDIEQI AKETKEKILR LLTSTSTDVS HQQFMTSGFE DKQSTCETKE QEP
Highest antigen sequence identity to orthologs:
- Mouse: 78%
- Rat: 83%
Target Information
USP51 (Ubiquitin Specific Peptidase 51) is a protein-coding gene involved in the Ubiquitin-Proteasome Dependent Proteolysis pathway.
Gene Ontology (GO) annotations include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity.
USP51 specifically deubiquitinates Lys-14 (H2AK13Ub) and Lys-16 (H2AK15Ub) of histone H2A, regulating DNA damage response at double-strand breaks (DSBs).
It is recruited to chromatin after DNA damage and regulates the assembly/disassembly of TP53BP1 and BRCA1.
Also exhibits activity for Lys-27 or Lys-63-linked di-ubiquitin.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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