Thermo Fisher Scientific TAGLN2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TAGLN2. Recombinant protein control fragment (Product #RP-102024). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TAGLN2,uniProtId:P37802-1,ncbiNodeId:9606,antigenRange:4-136,antigenLength:199,antigenImageFileName:PA5-51664_TAGLN2_P37802-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51664_TAGLN2_P37802-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648206

Product Specific Information

Immunogen sequence: RGPAYGLSRE VQQKIEKQYD ADLEQILIQW ITTQCRKDVG RPQPGRENFQ NWLKDGTVLC ELINALYPEG QAPVKKIQAS TMAFKQMEQI SQFLQAAERY GINTTDIFQT VDLWEGKNMA CVQRTLMNLG GLA

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Target Information

Transgelin (also designated SM22alpha), is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. The human transgelin-2 gene (designated TAGLN2), which is located on chromosome 1q231-q25, encodes a 199 amino acid protein that contains a calponin-like repeat and a calponin-homology (CH) domain. Transgelin-2 may function very similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.