Thermo Fisher Scientific TAGLN2 Polyclonal Antibody
TAGLN2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피 정제. Human, Mouse, Rat 반응성. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TAGLN2. Recombinant protein control fragment (Product #RP-102024). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648206 |
Product Specific Information
Immunogen sequence:
RGPAYGLSRE VQQKIEKQYD ADLEQILIQW ITTQCRKDVG RPQPGRENFQ NWLKDGTVLC ELINALYPEG QAPVKKIQAS TMAFKQMEQI SQFLQAAERY GINTTDIFQT VDLWEGKNMA CVQRTLMNLG GLA
Highest antigen sequence identity to orthologs:
Mouse – 95%, Rat – 95%
Target Information
Transgelin (also designated SM22alpha) is abundantly expressed in smooth muscle cells.
Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is expressed in smooth muscle cells and peritoneal B-1 cells.
The human transgelin-2 gene (TAGLN2), located on chromosome 1q23.1–q25, encodes a 199 amino acid protein containing a calponin-like repeat and a calponin-homology (CH) domain.
Transgelin-2 may function similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac, and skeletal muscle, but later restricted to vascular and visceral smooth muscle cells and low levels in the heart.
Transgelin is downregulated in several transformed cell lines, suggesting reduced expression may indicate early transformation onset.
Transgelin binds actin, causing actin fibers to gel within minutes of binding, at a ratio of 1:6 actin monomers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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