Thermo Fisher Scientific IKAP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues I(148) H Q D D F G E S K F I T V(161) of huamn IKAP. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IKAP,uniProtId:O95163-1,ncbiNodeId:9606,antigenRange:148-161|149-161,antigenLength:1332,antigenImageFileName:PA1-4163_IKAP_O95163-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4163_IKAP_O95163-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2122035

Product Specific Information

PA1-4163 detects IKAP in human samples.

PA1-4163 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing IKAP in Interleukin-1-stimulated 293 cells.

The PA1-4163 immunogen is a synthetic peptide corresponding to residues I(148) H Q D D F G E S K F I T V(161) of huamn IKAP. This sequence is 92% conserved in rat, and 85% conserved in mouse.

Target Information

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.