Thermo Fisher Scientific ADAMTS2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: A-375, U-87MG, THP-1, Rat thymus
• Cellular Location: Extracellular matrix, extracellular space

Immunogen Sequence:
PRNISDPSKK SYVVQWLSRP DPDSPIRKIS SKGHCQGDKS IFCRMEVLSR YCSIPGYNKL CCKSCNLYNN LTNVEGRIEP PPGKHNDIDV FMPTLPVPTV AMEVRPSPST PLEVPLNASS TNATEDHPET NAVDEPYKIH GLEDEVQPPN LIPRRPSPYE KTRNQRIQEL IDEMRKKEML GKF

Target Information

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, II, and V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in two transcript variants; the short transcript encodes a protein lacking significant procollagen N-peptidase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.