Thermo Fisher Scientific Smad1 Polyclonal Antibody, Biotin
Smad1 단백질을 인식하는 Thermo Fisher Scientific의 Biotin 결합 Rabbit Polyclonal Antibody입니다. Western blot, ELISA, Immunoprecipitation 등 다양한 응용에 적합하며, 고순도 Affinity Chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Fruit fly |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 405–455 of D. melanogaster Mothers against dpp protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, containing 30% glycerol and 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the gene products of Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates bone morphogenetic protein (BMP) signaling, which regulates cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, the protein is phosphorylated and activated by BMP receptor kinases, forming a complex with SMAD4 for transcriptional regulation. It is a target for SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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