Thermo Fisher Scientific ROS1 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500 dilution

Product Specifications

Product Specific Information

Immunogen sequence:
WKYNEFYHVK TSCSQGPAYV CNITNLQPYT SYNVRVVVVY KTGENSTSLP ESFKTKAGVP NKPGIPKLLE GSKNSIQWEK AEDNGC

Target Information

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases transfer a phosphate group from ATP to substrate proteins, mediating most signal transduction in eukaryotic cells. They regulate cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family includes over 500 gene products and is divided into 8 major groups based on sequence comparison of catalytic domains. The tyrosine kinase group primarily regulates cell-cell interactions such as differentiation, adhesion, motility, and death. Approximately 90 TK genes have been sequenced — 58 receptor TKs (EGFR, EPH, FGFR, PDGFR, TRK, VEGFR families) and 32 cytosolic TKs (ABL, FAK, JAK, SRC families).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.