Thermo Fisher Scientific LATS2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LATS2 protein kinase. Suitable for ICC/IF applications at 0.25–2 µg/mL. Unconjugated liquid form, 0.3 mg/mL concentration. For research use only; not for diagnostic procedures.
- 카탈로그번호
- PA583944
- 판매단위
- pk
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Thermo Fisher Scientific LATS2 Polyclonal Antibody
Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LATS2 (Product #RP-106215) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791096 |
Product Specific Information
Immunogen sequence:
ALEYISKMGY LDPRNEQIVR VIKQTSPGKG LMPTPVTRRP SFEGTGDSFA SYHQLSGTPY EGPSFGADGP TALEEMPRPY VDYLFPGVGP HGPGHQHQHP PKGYGASVEA AGAHFPL
Target Information
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. It interacts with a negative regulator of p53 and functions in a positive feedback loop with p53 that responds to cytoskeleton damage, provoking centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in maintaining mitotic fidelity and genomic integrity, and regulates organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The pathway involves a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1. This in turn phosphorylates and inactivates YAP1 and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, regulating genes important for cell proliferation, death, and migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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