Thermo Fisher Scientific CHKB Polyclonal Antibody
인간 CHKB 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 40% 글리세롤 포함. 세포 성장 및 인지질 합성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CHKB. Recombinant protein control fragment (Product #RP-92367). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639768 |
Product Specific Information
Immunogen sequence:
CEWVYDYTHE EWPFYKARPT DYPTQEQQLH FIRHYLAEAK KGETLSQEEQ RKLEEDLLVE VSRYALASHF FWGLWS
Antigen sequence identity:
- Mouse: 84%
- Rat: 84%
Target Information
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway.
Choline kinase, the initial enzyme in the sequence, plays a role in cell growth and proliferation.
A related protein, ChoKB (choline kinase beta), is a 395 amino acid enzyme that catalyzes the phosphorylation of choline by ATP in the presence of magnesium, producing phosphocholine and ADP.
ChoKB also exhibits ethanolamine kinase activity and catalyzes the phosphorylation of ethanolamine.
The gene encoding ChoKB is located less than 1 kb upstream of the CPT1B gene, suggesting potential transcriptional regulation between them.
In mice, mutations or deletions in the ChoKB gene cause hindlimb muscular dystrophy and neonatal bone deformity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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