Thermo Fisher Scientific ST3GAL6 Polyclonal Antibody
Human ST3GAL6 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.4 mg/mL 농도의 액상 형태로 제공. ST3GAL6 관련 암 연구 및 당전이효소 기전 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ST3GAL6. Recombinant protein control fragment (Product #RP-89966) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647969 |
Product Specific Information
Immunogen sequence:
IQPCLSKPAF ASLLRFHQFH PFLCAADFRK IASLYGSDKF DLPYGMRTSA EYFRLALSKL QSCDLFDEFD NIPCKKCVVV GNGGVLKNKT LGEKIDSYDV IIRMNNG
- Highest antigen sequence identity to the following orthologs:
- Mouse: 71%
- Rat: 75%
Target Information
Sialyltransferases catalyze the transfer of sialic acid from CMP-NeuAc to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures such as sialyl-Lewis X and are widely distributed in many cell types.
Cancer cells often express more heavily sialylated glycans on their surface, correlating with invasiveness. Expression of ST3GAL6, a member of the sialyltransferase family that sialylates type II lactosamine structures, is decreased by hypermethylation in gastrointestinal cancer.
At least three isoforms of ST3GAL6 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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