Thermo Fisher Scientific ST3GAL6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ST3GAL6. Recombinant protein control fragment (Product #RP-89966). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ST3GAL6,uniProtId:Q9Y274-1,ncbiNodeId:9606,antigenRange:42-148,antigenLength:331,antigenImageFileName:PA5-53845_ST3GAL6_Q9Y274-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53845_ST3GAL6_Q9Y274-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647969

Product Specific Information

Immunogen sequence: IQPCLSKPAF ASLLRFHQFH PFLCAADFRK IASLYGSDKF DLPYGMRTSA EYFRLALSKL QSCDLFDEFD NIPCKKCVVV GNGGVLKNKT LGEKIDSYDV IIRMNNG

Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 75%.

Target Information

Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.