Thermo Fisher Scientific CD11b Recombinant Rabbit Monoclonal Antibody (ARC0414)
Thermo Fisher Scientific의 CD11b Recombinant Rabbit Monoclonal Antibody (ARC0414)는 인간 CD11b/ITGAM을 인식하는 고특이성 항체로, WB, IHC, Flow Cytometry, ELISA에 적합합니다. HEK293 발현 시스템에서 생산되며, 액상 형태로 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0414 |
| Immunogen | Synthetic peptide corresponding to amino acids 1053–1152 of human CD11b/ITGAM (P11215) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849103 |
Product Specific Information
Immunogen sequence:
FDWYIKTSHN HLLIVSTAEI LFNDSVFTLL PGQGAFVRSQ TETKVEPFEV PNPLPLIVGS SVGGLLLLAL ITAALYKLGF FKRQYKDMMS EGGPPGAEPQ
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- Subsets of NK cells and dendritic cells
- Microglia in the brain
CD11b/CD18 acts as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X. These interactions are essential for cell-cell and cell-matrix adhesion.
Expression patterns:
- 8% of spleen cells
- 44% of bone marrow cells
- <1% of thymocytes
CD11b is commonly used as a microglial marker in nervous tissue. Its expression increases during monocyte maturation and varies among tissue macrophages. Peritoneal macrophages express higher levels than splenic macrophages.
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to lupus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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