Thermo Fisher Scientific LYAR Polyclonal Antibody
LYAR 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합합니다. 인간과 생쥐 시료에 반응하며, 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보관되며, 연구용으로만 사용 가능합니다.
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- PA5101505
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LYAR (Accession Q9NX58), corresponding to amino acid residues K250–D300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850940 |
Product Specific Information
Antibody detects endogenous levels of total LYAR.
Target Information
LYAR plays a role in the maintenance of appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227).
Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918).
In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 (PubMed:28686580).
Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918).
Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131).
In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131).
Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells.
Prevents nucleolin (NCL) self-cleavage, maintaining normal steady-state levels of NCL protein in undifferentiated embryonic stem cells (ESCs), which is essential for ESC self-renewal. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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