Thermo Fisher Scientific HLA-DR/DP Monoclonal Antibody (MEM-136), FITC

Thermo Fisher Scientific HLA-DR/DP Monoclonal Antibody (MEM-136), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 20 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA1-19227)
• APC (MA1-10349)
• Biotin (MA1-10350)
• PE (MA1-10353)
• Request custom conjugation

Product Specific Information

This antibody reacts with alpha/beta dimer as well as with dissociated beta-subunit. DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Target Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
The alpha chain is approximately 33–35 kDa and its gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA does not have polymorphisms in the peptide-binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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