Thermo Fisher Scientific Phospho-RBM4 (Ser309) Polyclonal Antibody
Phospho-RBM4 (Ser309) 폴리클로날 항체로 인간, 생쥐, 랫트 반응성. Western blot, ELISA, IP에 사용 가능. 인산화 합성 펩타이드(aa 300-350)로 면역원 제작. 액상 형태, 친화 크로마토그래피로 정제, -20°C 보관.
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Thermo Fisher Scientific Phospho-RBM4 (Ser309) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphorylated synthetic peptide within amino acid region 300–350 on human RNA binding motif protein 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RNA-binding factor involved in multiple aspects of cellular processes such as alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5′-splice site and exon selection and acts as a muscle cell differentiation-promoting factor. Activates exon skipping of PTB pre-mRNA during muscle cell differentiation and antagonizes PTBP1 to modulate muscle-specific exon selection of alpha tropomyosin.
Binds to intronic pyrimidine-rich sequences of TPM1 and MAPT pre-mRNAs and is required for translational activation of PER1 mRNA in response to the circadian clock. Suppresses Cap-dependent translation by binding CU-rich elements within 3′UTR of mRNAs, enhanced under stress or during myocyte differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation under stress and associates with AGO2-containing miRNPs for miRNA-guided RNA cleavage and translation suppression. Prefers binding to 5′-CGCGCG[GCA]-3′ motif in vitro. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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