Thermo Fisher Scientific Phospho-c-Met (Tyr1230, Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (5H27L59)
Phospho-c-Met (Tyr1230, Tyr1234, Tyr1235)에 특이적인 재조합 토끼 단클론 항체로, WB, IHC, ICC, ELISA에 적합. 높은 특이성과 민감도, 로트 간 일관성, 동물 유래 성분 무함유. 암 연구 및 신호전달 분석에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–3 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 2–3 µg/mL | - |
| ELISA | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5H27L59 |
| Immunogen | Proprietary |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532286 |
Product Specific Information
This antibody is predicted to react with bovine, feline, mouse, and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as a ~150 kDa band and upon reduction generates a ~25 kDa light chain and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone the specific antibody DNA sequences from immunoreactive rabbits and screen individual clones for optimal performance.
Advantages of recombinant rabbit monoclonal antibodies:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal-origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
MET (cMET) is a receptor-like tyrosine kinase associated with various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC.
Biological roles of MET:
- Embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation)
- Adult functions (wound healing, organ regeneration, tissue remodeling)
Clinical relevance:
MET dysregulation is linked to cancers such as gastric, renal, and breast, making it a key target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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