Thermo Fisher Scientific PALB2 Monoclonal Antibody (OTI1E7), TrueMAB
PALB2 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI1E7). Western blot에 최적화되어 있으며, Human 시료에 반응합니다. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. PALB2-BRCA 상호작용 연구에 적합합니다.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–287 of human PALB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are key factors in DNA damage repair by homologous recombination, associated with inherited breast and ovarian cancers.
PALB2 is essential for BRCA2 localization to DNA damage sites and functions as a breast cancer susceptibility gene. It interacts directly with BRCA1, organizing BRCA2 and RAD51 at DNA damage sites.
Analysis of the BRCA1–PALB2–BRCA2–RAD51 network may help predict tumor responsiveness to therapeutic treatments.
At least four isoforms of PALB2 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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