Thermo Fisher Scientific CYLD Monoclonal Antibody (2F9)
인간 CYLD 단백질을 인식하는 Mouse IgG2a 단클론 항체로 ELISA에 적합합니다. GST 태그 결합 재조합 단백질을 면역원으로 사용하였으며, PBS 용액 형태로 제공됩니다. 종양 억제 단백질 CYLD 연구 및 신호전달 경로 분석에 활용 가능합니다.
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Applications
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F9 |
| Immunogen | CYLD (AAH12342, 854–953 a.a.) 부분 재조합 단백질 (GST tag 포함, GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QNMELFAVLC IETSHYVAFV KYGKDDSAWL FFDSMADRDG GQNGFNIPQV TPCPEVGEYL KMSLEDLHSL DSRRIQGCAR RLLCDAYMCM YQSPTMSLYK
Target Information
CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, an SH3 binding domain, and a catalytic domain homologous to UCH.
CYLD acts as a tumor suppressor affecting the JNK signaling pathway and negatively regulates TRAF2 and NF-κB signaling. It also modulates the I-κB kinase pathway and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. TRAP1 has been identified as a novel substrate for CYLD.
Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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