Thermo Fisher Scientific CYP2D6 Monoclonal Antibody (2C5)
인간 CYP2D6 단백질을 인식하는 Mouse IgG2a 단클론 항체입니다. ELISA에 적합하며, 약물 대사 연구와 CYP2D6 관련 효소 기능 분석에 활용됩니다. PBS 용액 형태로 제공되며, -20°C에서 보관합니다.
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Applications
- ELISA (ELISA): Tested dilution 3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C5 |
| Immunogen | CYP2D6 (NP_000097, 91 a.a. – approximately 190 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LVTHGEDTAD RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT
Target Information
Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. CYP2D6 localizes to the endoplasmic reticulum and metabolizes approximately 20% of commonly prescribed drugs, including debrisoquine, sparteine, propafenone, and amitriptyline.
The gene is highly polymorphic, with some alleles leading to a poor metabolizer phenotype. It is located on chromosome 22q13.1 near two cytochrome P450 pseudogenes. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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