Thermo Fisher Scientific CYLD Monoclonal Antibody (2C3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
QNMELFAVLC IETSHYVAFV KYGKDDSAWL FFDSMADRDG GQNGFNIPQV TPCPEVGEYL KMSLEDLHSL DSRRIQGCAR RLLCDAYMCM YQSPTMSLYK

Target Information

CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, a SH3 binding domain, and a catalytic domain homologous to UCH.
CYLD acts as a tumor suppressor protein affecting the JNK signaling pathway, and negatively regulates TRAF2 and NF-kappa-B signaling. It also regulates the I-kappa-B kinase pathway and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. TRAP1 is a novel substrate for CYLD deubiquitination.
Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.