Thermo Fisher Scientific PLZF Monoclonal Antibody (Mags.21F7), Brilliant Violet 711, eBioscience
인간 및 생쥐 PLZF 단백질 검출용 단일클론 항체로, Brilliant Violet 711 형광체 결합. Flow Cytometry에 최적화되어 있으며, 세포내 염색에 적합. 높은 특이성과 안정성, 광민감성 주의 필요.
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Thermo Fisher Scientific PLZF Monoclonal Antibody (Mags.21F7), Brilliant Violet 711, eBioscience
Applications
- Flow Cytometry (Intracellular staining)
Tested Dilution: 1.0 µg/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Brilliant Violet™ 711 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Mags.21F7 |
| Conjugate | Brilliant Violet™ 711 |
| Excitation / Emission Max | 406 / 711 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_3093244 |
Additional Formats
- Alexa Fluor 488
- PE
- Request custom conjugation
Product Specific Information
This Mags.21F7 monoclonal antibody reacts with human and mouse promyelocytic leukemia zinc finger (PLZF), a transcriptional repressor belonging to the BTB-POZ family.
PLZF is expressed differently in mice and humans:
- Mouse: Immature CD1d-restricted NKT2, NKT1 cells, and subsets of γδ T cells.
- Human: NK cells, γδ T cells, CD4 and CD8+ T cells, MR1-specific MAIT cells, and MHC Class II-restricted T cells.
PLZF functions in NKT cell development, NK cell activity, cellular quiescence, and growth suppression. It inhibits gene expression induced by retinoic acid receptor.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Tested on mouse thymocytes using Foxp3/Transcription Factor Staining Buffer Set (Product #00-5523-00). Recommended ≤1.0 µg/test. Optimize antibody titration per assay.
Brilliant Violet™ 711 (BV711):
- Tandem dye emitting at 713 nm (violet laser, 405 nm excitation).
- Use Super Bright Complete Staining Buffer (SB-4401-42) or Brilliant Stain Buffer™ (00-4409-75) when combining multiple polymer dyes.
- Light sensitive: protect from light.
- Fixation: Compatible with IC Fixation Buffer (00-8222-49) or Fix/Lyse Solution (00-5333-54).
Not compatible with methanol-based fixation.
Excitation: 407 nm
Emission: 713 nm
Laser: Violet Laser
BRILLIANT VIOLET™ is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, used under license. Powered by Sirigen™.
Target Information
PLZF gene encodes a Krueppel-type zinc finger transcription factor located in the nucleus, involved in cell cycle progression and histone deacetylase interaction. Aberrant rearrangements are associated with acute promyelocytic leukemia (APL). Alternate splice variants have been identified.
For Research Use Only. Not for use in diagnostic procedures.
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