Thermo Fisher Scientific ATP2C2 Polyclonal Antibody
ATP2C2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC에 사용 가능하며, 인체 시료에 반응. 합성 펩타이드(aa 10–60)를 면역원으로 사용. 동결건조 형태로 제공되며, 연구용으로만 사용 가능.
- 카탈로그번호
- OSA00265W-100UL
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 10–60 of human ATP2C2 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C (short term). For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ATP2C2.
Target Information
ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), is a P-type cation transport ATPase. This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, which ATP2C2 does not compensate for, suggesting distinct physiological roles. ATP2C2 shows restricted expression and higher maximal turnover for Ca²⁺-ATPase activity, with lower affinity for cytosolic Ca²⁺. Overexpression in mammary tumors induces Ca²⁺ influx via ORAI1, independent of STIM1/STIM2 sensors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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