Thermo Fisher Scientific Aggrecan Polyclonal Antibody
Thermo Fisher Scientific의 Aggrecan Polyclonal Antibody는 인간 Aggrecan 단백질을 인식하는 토끼 유래 항체로, WB 및 IHC에 적합합니다. 합성 펩타이드(aa 1440–1490)를 면역원으로 사용하며, cartilage matrix 연구 및 연골 손상 관련 단백질 분석에 활용됩니다.
- 카탈로그번호
- OSA00262W-100UL
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
- Publications: View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: View 1 publication
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1440–1490 of human Aggrecan conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide shares 92% identity with rat and mouse sequences.
- Specificity: Aggrecan.
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene.
It is a major component of the extracellular matrix in cartilage, providing resistance to compression.
The human protein (approx. 250 kDa, 2316 amino acids) exists in multiple isoforms due to alternative splicing.
Aggrecan has a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to its core.
It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Aggrecan fragments are released into synovial fluid during osteoarthritis progression due to cleavage by aggrecanase and MMPs.
Antibodies BC-3 and BC-4 can detect neo-epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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