Thermo Fisher Scientific KLF10 Monoclonal Antibody (4D12)
KLF10 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며 PBS buffer에 보관됩니다. TGF-beta 신호 조절 및 세포 성장 억제 연구에 활용됩니다.
- 카탈로그번호
- H00007071-M56
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D12 |
| Immunogen | KLF10 (AAH11538.1, 1–110 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers.
It functions as a transcriptional repressor involved in the regulation of cell growth and apoptosis.
KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation.
It may inhibit Smad7 expression in bronchial epithelial cells and is ubiquitously expressed in most tissues.
Overexpression of KLF10 has been associated with renal clear cell carcinoma and other tumors.
KLF11, a related zinc finger transcription factor, binds to SP1-like sequences and is associated with maturity-onset diabetes of the young type 7 (MODY7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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