Thermo Fisher Scientific KLF10 Monoclonal Antibody (4G2)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS

Target Information

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers.
KLF10 acts as a transcriptional repressor regulating cell growth and apoptosis. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta signaling to pancreatic epithelial cell growth regulation.

It is ubiquitously expressed in most tissues and may mediate up-regulation of TGFBI in VHL-deficient tumors. Overexpression of KLF10 has been associated with renal clear cell carcinoma and other cancers.

KLF11, a related zinc finger transcription factor, binds to SP1-like sequences in epsilon- and gamma-globin gene promoters, inhibiting cell growth and inducing apoptosis. Defects in this gene cause maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.