Thermo Fisher Scientific KLF10 Monoclonal Antibody (4G2)
KLF10 단백질을 인식하는 Thermo Fisher Scientific의 Mouse 단일클론 항체(4G2)입니다. Western blot 및 ELISA에 적합하며, 인간 시료 반응성을 보입니다. PBS 완충액에 보존되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G2 |
| Immunogen | KLF10 (AAH11538.1, 1–110 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers.
KLF10 acts as a transcriptional repressor regulating cell growth and apoptosis. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta signaling to pancreatic epithelial cell growth regulation.
It is ubiquitously expressed in most tissues and may mediate up-regulation of TGFBI in VHL-deficient tumors. Overexpression of KLF10 has been associated with renal clear cell carcinoma and other cancers.
KLF11, a related zinc finger transcription factor, binds to SP1-like sequences in epsilon- and gamma-globin gene promoters, inhibiting cell growth and inducing apoptosis. Defects in this gene cause maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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