Thermo Fisher Scientific KLF10 Monoclonal Antibody (3F7)
KLF10 단백질을 표적으로 하는 Mouse IgG2a monoclonal antibody. Western blot 및 ELISA에 적합하며, 인간 시료 반응성. Affinity chromatography로 정제된 액상 형태로 제공되며, PBS buffer에 보존제 미포함. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific KLF10 Monoclonal Antibody (3F7)
Thermo Fisher Scientific KLF10 Monoclonal Antibody (3F7)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F7 |
| Immunogen | KLF10 (AAH11538.1, 1–110 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell regulation. KLF10 promotes apoptosis through the mitochondrial pathway and may inhibit Smad7 expression in bronchial epithelial cells.
It is ubiquitously expressed in tissues and may mediate up-regulation of TGFBI in VHL-deficient tumors. Overexpression is associated with renal clear cell carcinoma and other cancers.
KLF11, a related zinc finger transcription factor, binds SP1-like sequences to inhibit cell growth and induce apoptosis. Defects in KLF11 cause maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.