Thermo Fisher Scientific KLF10 Monoclonal Antibody (5G9)
KLF10 단백질을 인식하는 Mouse IgG2a 형 단일클론 항체로, Western blot 및 ELISA에 적합합니다. 인간 시료 반응성이 있으며, PBS 용액 형태로 제공됩니다. TGF-beta 관련 세포 성장 및 전사 조절 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5G9 |
| Immunogen | KLF10 (AAH11538.1, 111–210 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LSDTAKPHIA APFKEEEKSP VSAPKLPKAQ ATSVIRHTAD AQLCNHQTCP MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers.
It acts as a transcriptional repressor involved in the regulation of cell growth and apoptosis.
KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation.
It may inhibit Smad7 expression and is ubiquitously expressed in most tissues.
Overexpression of KLF10 has been associated with renal clear cell carcinoma and other tumors.
KLF11, a related zinc finger transcription factor, binds SP1-like sequences and is linked to MODY7 diabetes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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