Thermo Fisher Scientific PAX8 Polyclonal Antibody
PAX8 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP, ChIP 등 다양한 응용 가능. 인간 및 비인간 영장류 반응성. 고순도 Protein G 정제, -20°C 보관.
- 카탈로그번호
- PA1112
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg |
| ChIP assay (ChIP) | – |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified internal fragment of human recombinant PAX8 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539884 |
Product Specific Information
Western blot analysis of PA1-112 detects a prominent ~48 kDa protein in human adenocarcinoma SKOV-3 and SV40 transformed African green monkey (Cercopithecus aethiops) kidney cells.
In SKOV-3 cells, two additional unknown bands at ~20 kDa and ~150 kDa are also detected.
Specificity was confirmed in HeLa and 293T cells overexpressing full-length PAX8.
The 48 kDa band is enriched in immunoprecipitations from Cos7 lysate, although additional unknown high molecular weight bands are also enriched and detected by PA1-112.
Target Information
This gene encodes a member of the paired box family of transcription factors.
Members of this family typically encode proteins containing a paired box domain, an octapeptide, and a paired-type homeodomain.
This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes.
Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical follicular thyroid adenomas.
Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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