Thermo Fisher Scientific BCAS1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues 532-550 of human BCAS1/NABC1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BCAS1,uniProtId:O75363-1,ncbiNodeId:9606,antigenRange:532-550,antigenLength:584,antigenImageFileName:PA1-10886_BCAS1_O75363-1_Rabbit.svg,antigenImageFileNamePDP:PA1-10886_BCAS1_O75363-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_11001619

Product Specific Information

PA1-10886 detects BCAS1 / NABC1 in human samples.

PA1-10886 has been successfully used in Western blot procedures. A band of approximately 60 kDa is detected by Western blot; however, prtein dimerization may occur.

PA1-10886 immunogen is a synthetic peptide corresponding to residues 532-550 of human BCAS1/NABC1.

Target Information

BCAS1 was identified through positional cloning and was found to be overexpressed in most but not all breast cancer cells lines. Little is known about this protein; BCAS1 is cytoplasmically localized and is thought to form homodimers through coiled-coil structures. High levels of BCAS1 mRNA are seen in brain and prostate tissues, with lower amounts observed in colon, intestine and testis. Cells engineered to overexpress BCAS1 did not lose anchorage-dependent growth or increase their rate of growth, suggesting that BCAS1 is not a prototypical oncogene. The BCAS1 gene was also found to be amplified in other carcinomas such as pancreatic carcinoma, suggesting that BCAS1 may play in important role in the control of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.