Thermo Fisher Scientific NEDD-9/CASL/HEF1 Recombinant Rabbit Monoclonal Antibody (BLR248L)
상품 옵션 정보 | ||||||||
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
A700-248 | - | Thermo Fisher Scientific A700-248 NEDD-9/CASL/HEF1 Recombinant Rabbit Monoclonal Antibody (BLR248L) 100 uL pk | 재고문의 | pk | 0원 | - | 0원 | |
A700-248-T | - | Thermo Fisher Scientific A700-248-T NEDD-9/CASL/HEF1 Recombinant Rabbit Monoclonal Antibody (BLR248L) 20 uL pk | 재고문의 | pk | 0원 | - | 0원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
Immunoprecipitation (IP)
6 µL/mg of lysate
Product Specifications
Species Reactivity
Human, Mouse
Host/Isotype
Rabbit / IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR248L
Immunogen
Peptide representing a region between residue 150 and 200 of Human Enhancer of filamentation 1 (aka NEDD-9). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
HEF1,
uniProtId:
Q14511-1,
ncbiNodeId:
9606,
antigenRange:
150-200,
antigenLength:
834,
antigenImageFileName:
A700-248_HEF1_Q14511-1_Rabbit.svg,
antigenImageFileNamePDP:
A700-248_HEF1_Q14511-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
purified
Storage buffer
BBS, pH 8.2
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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