Thermo Fisher Scientific BRCC3 Polyclonal Antibody
BRCC3 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체. Western blot에 적합하며 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. DNA 손상 반응 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRCC3 (Accession P46736), corresponding to amino acid residues A63–R113 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852329 |
Product Specific Information
This antibody detects endogenous levels of total BRCC3.
Target Information
BRCC36 forms a holoenzyme complex with BRCA1, BRCA2, RAD51, and BRCC45, possessing ubiquitin E3 ligase activity. Aberrant levels of BRCC36 are found in sporadic breast tumors. Depletion of BRCC36 or BRCC45 increases sensitivity to ionizing radiation and causes G2/M checkpoint defects, indicating BRCC36 enhances cellular survival following DNA damage. It is essential for BRCA1 phosphorylation and nuclear foci formation after radiation, suggesting its potential as a therapeutic target in radiation-resistant breast tumors. At least two isoforms of BRCC36 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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