Thermo Fisher Scientific CD38 Monoclonal Antibody (HIT2), Biotin, eBioscience
인간 CD38 단백질을 인식하는 HIT2 단클론 항체로, Biotin으로 표지되어 있습니다. Flow cytometry에 최적화되어 있으며, B세포·T세포 활성화 연구에 사용됩니다. 고순도 친화 크로마토그래피 정제, 4°C 암소 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.5 µg/test | View 13 publications |
| ELISA | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIT2 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, Do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_529519 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 480
- eFluor 450
- FITC
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 702
- Request custom conjugation
Product Specific Information
Description:
The HIT2 monoclonal antibody reacts with human CD38, an approximately 45 kDa type II transmembrane protein expressed on thymocytes, peripheral B cells (including plasma cells), activated T cells, and monocytes. CD38 serves as a counter-receptor for CD31 and exhibits both cyclase and hydrolase enzymatic activity.
Applications Reported:
This HIT2 antibody is reported for use in flow cytometric analysis.
Applications Tested:
Tested in flow cytometric analysis of normal human peripheral blood cells. Recommended usage is ≤0.5 µg per test (defined as the amount of antibody that stains a cell sample in 100 µL final volume). Optimal cell number ranges from 10⁵ to 10⁸ cells/test and should be empirically determined. Antibody titration is recommended for best performance.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD38 (NAD⁺ glycohydrolase):
CD38 is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of lymphocytes, as well as apoptosis of progenitor cells. It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and NAD⁺ glycohydrolase) and as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping lymphomas and leukemias
- Detecting plasma cells (e.g., myeloma identification)
- Serving as markers for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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